ESB Clinical Biomechanics Award 2020: Pelvis and hip movement strategies discriminate typical and pathological femoral growth - Insights gained from a multi-scale mechanobiological modelling framework

ESB Clinical Biomechanics Award 2020: Pelvis and hip movement strategies discriminate typical and pathological femoral growth – Insights gained from a multi-scale mechanobiological modelling framework

Many kids with cerebral palsy (CP) develop skeletal deformities throughout childhood. Thus far, it’s unknown why some kids with CP develop bony deformities whereas others don’t. The goals of this examine had been to (i) examine what loading traits result in typical and pathological femoral development, and (ii) consider why some kids with CP develop femoral deformities whereas different don’t.  Our simulation outcomes recognized particular gait options, which can contribute to pathological femoral development. Moreover, the hip joint contact pressure orientation within the sagittal aircraft appears to be the dominant issue for figuring out femoral development simulations.

A multi-scale mechanobiological modelling workflow was used to simulate femoral development based mostly on three-dimensional movement seize information of six usually growing kids and 16 kids with CP. Based mostly on the expansion outcomes, the individuals with CP had been divided into two teams: typical development group and pathological development group. Gait kinematics and femoral loading had been in contrast between simulations leading to typical development and people leading to pathologic development.

Hip joint contact forces had been much less posteriorly-oriented within the pathological development simulations in comparison with the standard ones. In comparison with the usually growing individuals, the CP group with pathological femoral development introduced elevated knee flexion and no hip extension.

The CP group with simulated typical development introduced comparable sagittal aircraft joint kinematics however differed within the frontal aircraft pelvic and hip motion technique, which normalized the hip joint contact pressure and subsequently contributed to typical femoral development tendencies.

The Root Extract of Scutellaria baicalensis Induces Apoptosis in EGFR TKI-Resistant Human Lung Most cancers Cells by Inactivation of STAT3

Resistance to epidermal development issue receptor tyrosine kinase inhibitors (EGFR TKIs) is a serious impediment in managing lung most cancers. The basis of Scutellaria baicalensis (SB) historically used for fever clearance and cleansing possesses numerous bioactivities together with anticancer results. The aim of this examine was to analyze whether or not SB exhibited anticancer exercise in EGFR TKI-resistant lung most cancers cells and to discover the underlying mechanism. We used 4 varieties of human lung most cancers cell strains, together with H1299 (EGFR wildtype; EGFR TKI-resistant), H1975 (acquired TKI-resistant), PC9/ER (acquired erlotinib-resistant), and PC9/GR (acquired gefitinib-resistant) cells.

The ethanol extract of SB (ESB) decreased cell viability and suppressed colony formation within the 4 cell strains. ESB stimulated nuclear fragmentation and the cleavage of poly(ADP-ribose) polymerase (PARP) and caspase-3. Persistently, the proportion of sub-G1 part cells and annexin V+ cells had been considerably elevated by ESB, indicating that ESB induced apoptotic cell loss of life in EGFR TKI-resistant cells. ESB dephosphorylated sign transducer and activator of transcription 3 (STAT3) and downregulated the goal gene expression. The overexpression of constitutively energetic STAT3 reversed ESB-induced apoptosis, suggesting that ESB triggered apoptosis in EGFR TKI-resistant cells by inactivating STAT3.

Taken collectively, we suggest the potential use of SB as a novel therapeutic for lung most cancers sufferers with EGFR TKI resistance. We subsequently explored the virulence of indigenous Brazilian strains of main entomopathogenic fungi-Beauveria spp. and Metarhizium anisopliae-against ESB adults. We discovered extensively various virulence and later capacities for conidial manufacturing on contaminated grownup cadavers.

ESB Clinical Biomechanics Award 2020: Pelvis and hip movement strategies discriminate typical and pathological femoral growth - Insights gained from a multi-scale mechanobiological modelling framework

Traits of carcass and physicochemical traits of meat from female and male geese fed a eating regimen based mostly on extruded soybean

Duck’ meat is characterised by good dietary properties and gaining recognition within the client market. Extruded soybean is doubtlessly extra digestible than generally use soybean meal (SBM), and is anticipated to affect carcass traits and the standard of breast and leg muscle tissues. The examine’ goal was to match meat high quality from each sexes’ geese fed a eating regimen with extruded soybean (ESB) as an alternative to SBM. Cherry Valley geese had been divided into two teams. The management group (1) was fed an SBM-based eating regimen, and the remedy group (2) with ESB.

Every group was divided into intercourse subgroups with 50 birds in every (5 replicates, 10 geese every). Dissection and evaluation of meats’ pH, color, water-holding capability (WHC), drip loss and chemical composition of breast and leg muscle tissues had been performed. Interplay of Weight loss plan and Intercourse was calculated. In group 2 increased carcass weight, dressing share, weight of wings, leg muscle tissues, complete muscle tissues, and higher WHC had been discovered. Dressing share, the proportion of neck with pores and skin, breasts’ and abdomen’ weight, and the load and proportion of fats, and pH45min had been increased in females (P < 0.05). The interplay was discovered for the pre-slaughter physique weight, the load of carcass stays, WHC in breasts (P < 0.05).

The ESB feed had no destructive impact on the analyzed traits and can be utilized within the geese’ eating regimen. Improved the WHC signifies the excessive suitability of meat for processing. A constructive impact of eating regimen on the muscle tissues’ proportion and dressing share was seen, which is essential for customers’ market. The sex-related variations and interactions between variables recommend separate rearing on account of intercourse.

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Nesbuvir

MBS386821-10mg 10mg
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Nesbuvir

MBS386821-50mg 50mg
EUR 1440

Nesbuvir

MBS386821-5mg 5mg
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MBS386821-5x50mg 5x50mg
EUR 6480

Nesbuvir

MBS5764347-50mg 50mg
EUR 1620

Nesbuvir

MBS5764347-5x50mg 5x50mg
EUR 7145

Nesbuvir, HCV-796

MBS130942-100mg 100mg
EUR 1065

Nesbuvir, HCV-796

MBS130942-500mg 500mg
EUR 2775

Z-FR-AMC 25mg

10201 25MG
EUR 167
Description: N/A

Z-FR-AMC 25mg

10201-1 EA
EUR 167

Cy 5 Maleimide 25Mg - EACH

PA15136 EACH
EUR 5432.4

Amersham Cy5.5 Maleimide 25mg - EACH

PA15636 EACH
EUR 4468.5

Deoxyribonuclease I (DNase I), 25mg

PC0704-25mg each Ask for price

Klebsiella Selective Supplement (25mg/vl)

29760 5 vl
EUR 10.26
Description: Part D

Goat Anti-Mouse IgG Fc, 25MG

A008-25MG 25MG
EUR 552.63

Goat Anti-Rabbit IgG Fc, 25MG

A009-25MG 25MG
EUR 552.63

Amersham CY3B NHS Ester 25MG - EACH

PA63106 EACH
EUR 6322.05

Chloramphenicol Solution, 25mg/mL in Methanol

40120754-1 25 tube(s)
EUR 79.62

Chloramphenicol Solution, 25mg/mL in Methanol

40120754-2 50 tube(s)
EUR 145.5

Streptomycin Sulfate Solution, 25mg/mL, Sterile

41910008-1 50 mL
EUR 43.56

Donkey Anti-Sheep IgG (H&L), 25MG

A010-25MG 25MG
EUR 552.63

Amersham Cy3 Mono NHS ester 25mg - EACH

PA13106 EACH
EUR 4062.15

Amersham Cy5 mono NHS ester 25mg - EACH

PA15106 EACH
EUR 5108.4

Amersham Cy5.5 mono NHS ester 25mg - EACH

PA15606 EACH
EUR 4468.5

Caffeine Standard 25mg/L in Water - 5ML

CAFSTD25005 5ML
EUR 275.4

OOMC00021-25MG - Carfilzomib

OOMC00021-25MG 25mg
EUR 269

OOMC00024-25MG - JQ1 (+)

OOMC00024-25MG 25mg
EUR 339

OOMC00027-25MG - Ascomycin

OOMC00027-25MG 25mg
EUR 169

OOMC00031-25MG - Dasatinib

OOMC00031-25MG 25mg
EUR 139

OOMC00032-25MG - Everolimus

OOMC00032-25MG 25mg
EUR 199

OOMC00059-25MG - Baricitinib

OOMC00059-25MG 25mg
EUR 199

OOMC00062-25MG - Pridopidine

OOMC00062-25MG 25mg
EUR 429

OOMC00063-25MG - Selinexor

OOMC00063-25MG 25mg
EUR 269

OOMC00064-25MG - Bromosporine

OOMC00064-25MG 25mg
EUR 369

OOMC00068-25MG - S1RA

OOMC00068-25MG 25mg
EUR 399

OOMC00069-25MG - Siramesine

OOMC00069-25MG 25mg
EUR 329

OOMC00070-25MG - PRE084

OOMC00070-25MG 25mg
EUR 229

OOMC00073-25MG - SA4503

OOMC00073-25MG 25mg
EUR 299

OOMC00077-25MG - Ruxolitinib

OOMC00077-25MG 25mg
EUR 199

OOMC00084-25MG - Acalabrutinib

OOMC00084-25MG 25mg
EUR 199

OOMC00085-25MG - Volasertib

OOMC00085-25MG 25mg
EUR 369

OOMC00086-25MG - Favipiravir

OOMC00086-25MG 25mg
EUR 219

OOMC00087-25MG - Ponatinib

OOMC00087-25MG 25mg
EUR 229

OOMC00089-25MG - Boceprvir

OOMC00089-25MG 25mg
EUR 329

OOAU00079-25MG - Piceatannol

OOAU00079-25MG 25mg
EUR 289

OOAU00086-25MG - Sirtinol

OOAU00086-25MG 25mg
EUR 479

OOAU00087-25MG - Garcinol

OOAU00087-25MG 25mg
EUR 269

OOAU00092-25MG - IOX1

OOAU00092-25MG 25mg
EUR 579

OOAU00094-25MG - DMXAA

OOAU00094-25MG 25mg
EUR 669

IC Multi Elem (7) Anion Std 25mg/L in H2O - 250ML

IC-MIX1 250ML
EUR 279.07

ATPγS, 25mg * Shipped on DRY ICE must be shipped Overnight *

M-NU-406-25 -
EUR 400
Description: ATPγS, 25mg * Shipped on DRY ICE must be shipped Overnight *

OOMC00019-25MG - A77 1726

OOMC00019-25MG 25mg
EUR 199

OOMC00022-25MG - RVX-208

OOMC00022-25MG 25mg
EUR 369

OOMC00023-25MG - Dabrafenib (GSK2118436)

OOMC00023-25MG 25mg
EUR 199

OOMC00035-25MG - H89 - 2HCl

OOMC00035-25MG 25mg
EUR 429

OOMC00036-25MG - PD-325901

OOMC00036-25MG 25mg
EUR 259

OOMC00057-25MG - INK-128

OOMC00057-25MG 25mg
EUR 139

OOMC00058-25MG - Santacruzamate A

OOMC00058-25MG 25mg
EUR 219

OOMC00061-25MG - N4-Hydroxycytidine

OOMC00061-25MG 25mg
EUR 329

OOMC00065-25MG - BI-2536

OOMC00065-25MG 25mg
EUR 369

OOMC00066-25MG - I-BET762

OOMC00066-25MG 25mg
EUR 399

OOMC00067-25MG - NE-100

OOMC00067-25MG 25mg
EUR 299

OOMC00072-25MG - BD1047 dihydrobromide

OOMC00072-25MG 25mg
EUR 269

OOMC00082-25MG - Palbociclib (PD0332991)

OOMC00082-25MG 25mg
EUR 199

OOMC00083-25MG - MK-2206

OOMC00083-25MG 25mg
EUR 229

OOAU00073-25MG - BML-278

OOAU00073-25MG 25mg
EUR 389

OOAU00075-25MG - EX-527

OOAU00075-25MG 25mg
EUR 389

OOAU00083-25MG - BML-210

OOAU00083-25MG 25mg
EUR 479

OOAU00084-25MG - C-646

OOAU00084-25MG 25mg
EUR 579

OOAU00088-25MG - BIX-01294

OOAU00088-25MG 25mg
EUR 369

OPPA00535-25MG - Insulin Protein

OPPA00535-25MG 25mg
EUR 154

OORA00210-25MG - DNA (Calf Thymus)

OORA00210-25MG 25mg
EUR 179

OOAU00076-25MG - FK-866 HCl

OOAU00076-25MG 25mg
EUR 539

OPSA10621-25MG - NATIVE UBIQUITIN Protein

OPSA10621-25MG 25mg
EUR 449

Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; EN 15662; 150mg MgSO4 and 25mg PSA; 2ml - PK100

CHR6480 PK100
EUR 189

OOSA09676-25MG - HORSERADISH PEROXIDASE Accessory Reagent

OOSA09676-25MG 25mg
EUR 369

OOMC00044-25MG - Miglustat HCl (N-Butyldeoxynojirimycin)

OOMC00044-25MG 25mg
EUR 479

OOMC00078-25MG - 7-Cl-O-Nec1

OOMC00078-25MG 25mg
EUR 259

OASB02218-25MG - Human ZAP-70 Antibody

OASB02218-25MG 25mg
EUR 99

OPPA01009-25MG - TP 5 - Thymopentin Protein

OPPA01009-25MG 25mg
EUR 70

OPSA10512-25MG - NATIVE Human FIBRINOGEN Protein

OPSA10512-25MG 25mg
EUR 199

OOMC00017-25MG - Ac-Leu-Leu-Methional (ALLM)

OOMC00017-25MG 25mg
EUR 229

OASB02220-25MG - Human ZAP-70 Antibody : FITC

OASB02220-25MG 25mg
EUR 129

OASB02224-25MG - Human ZAP-70 Antibody : Biotin

OASB02224-25MG 25mg
EUR 129

OASB02226-25MG - Human ZAP-70 Antibody : PE

OASB02226-25MG 25mg
EUR 139

OPSA10585-25MG - NATIVE Rabbit PHOSPHORYLASE B Protein

OPSA10585-25MG 25mg
EUR 219

Recombinant other Antide Protein, Untagged, E.coli-25mg

QP11028-25mg 25mg
EUR 663.6

Recombinant Salmon Calcitonin Protein, Untagged, E.coli-25mg

QP11261-25mg 25mg
EUR 1622.4

Recombinant Human Secretin Protein, Untagged, E.coli-25mg

QP13449-25mg 25mg
EUR 544.8

Recombinant other Sincalide Protein, Untagged, E.coli-25mg

QP13506-25mg 25mg
EUR 675.6

Recombinant other Goserelin Protein, Untagged, E.coli-25mg

QP12027-25mg 25mg
EUR 469.2

Recombinant other Histrelin Protein, Untagged, E.coli-25mg

QP12236-25mg 25mg
EUR 708

Recombinant other Lypressin Protein, Untagged, E.coli-25mg

QP12608-25mg 25mg
EUR 241.2

Recombinant other MOG Protein, Untagged, E.coli-25mg

QP12717-25mg 25mg
EUR 708

Recombinant Human OCT Protein, Untagged, E.coli-25mg

QP12920-25mg 25mg
EUR 1154.4

Recombinant Human OT Protein, Untagged, E.coli-25mg

QP12937-25mg 25mg
EUR 241.2

Recombinant other DDAVP Protein, Untagged, E.coli-25mg

QP11607-25mg 25mg
EUR 708

Recombinant Human Leuprorelin Protein, Untagged, E.coli-25mg

QP12555-25mg 25mg
EUR 349.2

Recombinant Human LHRH Protein, Untagged, E.coli-25mg

QP12569-25mg 25mg
EUR 218.4

Recombinant other Deslorelin Protein, Untagged, E.coli-25mg

QP11661-25mg 25mg
EUR 316.8

Recombinant Human Eptifibatide Protein, Untagged, E.coli-25mg

QP11802-25mg 25mg
EUR 241.2

Recombinant other Pramlintide Protein, Untagged, E.coli-25mg

QP13132-25mg 25mg
EUR 675.6

OOMC00055-25MG - MDL-28170 (Z-Val-Phe-CHO)

OOMC00055-25MG 25mg
EUR 269

OAAU00069-25MG - Goat Anti-Mouse IgG Fc Antibody

OAAU00069-25MG 25mg
EUR 519

OAAU00101-25MG - Goat Anti-Rabbit IgG Fc Antibody

OAAU00101-25MG 25mg
EUR 519

Recombinant Human Insulin Protein, Untagged, S. cerevisiae-25mg

QP10732-25mg 25mg
EUR 218.4

Recombinant Porcine Insulin Protein, Untagged, Native Protein-25mg

QP10733-25mg 25mg
EUR 218.4

Recombinant Multi Species Vasopressin Protein, Untagged, E.coli-25mg

QP13923-25mg 25mg
EUR 241.2

Recombinant other Thymosin ?1 Protein, Untagged, E.coli-25mg

QP13745-25mg 25mg
EUR 2350.8

Recombinant Human GHRP 2 Protein, Untagged, E.coli-25mg

QP11968-25mg 25mg
EUR 241.2

Recombinant other GHRP 6 Protein, Untagged, E.coli-25mg

QP11969-25mg 25mg
EUR 241.2

Recombinant Human EDN2 Protein, Untagged, Native Protein-25mg

QP11746-25mg 25mg
EUR 2416.8

Recombinant other TP 5 Protein, Untagged, E.coli-25mg

QP13789-25mg 25mg
EUR 186

Recombinant other Avidin Protein, Untagged, Native Protein-25mg

QP10525-25mg 25mg
EUR 241.2

OORA00203-25MG - Salmon Sperm DNA Ready-to-Use Solution

OORA00203-25MG 25mg
EUR 149

OAAU00102-25MG - Donkey Anti-Sheep IgG (H&L) Antibody

OAAU00102-25MG 25mg
EUR 519

Nestin (Cancer Stem Cell Marker)(NES/2911), 1mg/mL

BNUM2911-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), 0.2mg/mL

BNUB2911-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), 0.2mg/mL

BNUB2911-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF594 conjugate, 0.1mg/mL

BNC942911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF594 conjugate, 0.1mg/mL

BNC942911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF647 conjugate, 0.1mg/mL

BNC472911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF647 conjugate, 0.1mg/mL

BNC472911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF568 conjugate, 0.1mg/mL

BNC682911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF568 conjugate, 0.1mg/mL

BNC682911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF488A conjugate, 0.1mg/mL

BNC882911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF488A conjugate, 0.1mg/mL

BNC882911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF640R conjugate, 0.1mg/mL

BNC402911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF640R conjugate, 0.1mg/mL

BNC402911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF405S conjugate, 0.1mg/mL

BNC042911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), CF405S conjugate, 0.1mg/mL

BNC042911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), Biotin conjugate, 0.1mg/mL

BNCB2911-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nestin (Cancer Stem Cell Marker)(NES/2911), Biotin conjugate, 0.1mg/mL

BNCB2911-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nessler Reagent - 500ML

NESSR 500ML
EUR 205.2

Cylinder Nessler 100ml - PK2

C62144 PK2
EUR 27

Ampicillin (100mg/ml, 1000X)

K2801-10 10x1ml
EUR 64
Description: Cell Biology|Cell Culture

Ampicillin (100mg/ml, 1000X)

K2801-5 5x1ml
EUR 40
Description: Cell Biology|Cell Culture

Alkalinity Std 4000mg/L 4000ppm as CaCO3 - 500ML

TA4M05 500ML
EUR 405

Alkalinity Std 10000mg/L 10000ppm as CaCO3 - 500ML

TA10M5 500ML
EUR 421.2

Kanamycin (50mg/ml, 1000X)

K2802-10 10x1ml
EUR 64
Description: Cell Biology|Cell Culture

Kanamycin (50mg/ml, 1000X)

K2802-5 5x1ml
EUR 40
Description: Cell Biology|Cell Culture

Nitrate Std 1000mg/L as N - 500ML

SDN01000 500ML
EUR 454.95

Chloride Std 10000mg/L as Cl - 500ML

CLHY10M5 500ML
EUR 197.1

ICP Multi Elem (9) Std 1000mg/L - 100ML

ICPMIX-9-100 100ML
EUR 314.32

Nitrate Std 500mg/L as N - 500ML

SDN05005 500ML
EUR 395.55

ICP Multi Elem (11) Std in 3.5% HNO3 + 0.5% HF 1000mg/L - 250ML

ICP-MIX-CYM12 250ML
EUR 919.47

ICP Multi Elem (10) Std in 2% HNO3 1000mg/L - 100ML

ICP10-1000-100 100ML
EUR 615.43

ICP Multi Elem (11) Std in 5% HNO3 1000mg/L - 100ML

REICP11MIX4A 100ML
EUR 494.99

ICP Multi Elem (11) Std in 2% HNO3 1000mg/L - 500ML

REICPCAL11U 500ML
EUR 985.56

ICP Multi Elem (3) Std in 2% HCl Hg Ca Mg 100mg/L - 100ML

ICP-MET-3-100 100ML
EUR 170.38

ICP Multi Elem (9) Std in 2% HNO3 100mg/L - 100ML

ICP-MET-9-100 100ML
EUR 474.42

ICP Multi Elem (12) Std in 2-5% HNO3 100mg/L - 100ML

ICP12-100-100 100ML
EUR 640.4

A ferritic stainless-steel, Crofer 22 APU, is one in all candidates for metallic interconnects of stable oxide gas cells. Ferritic stainless-steel Crofer 22 APU specimens with totally different floor roughnesses had been ready by grinding with SiC powder papers of varied grits and had been then thermally cycled. Polished Crofer 22 APU specimens after one thermal cycle and 5 thermal cycles had comparatively straight oxide layers with comparable thicknesses of 30 μm, suggesting that after one cycle (complete oxygen publicity time of 100 h at 1073 Okay), the oxidation doesn’t progress.

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